MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics, pharmacogenomics, and individualized medicine.
Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...
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MicroRNAs are non-coding small RNAs that regulate gene expression by Watson-Crick base pairing to target messenger RNA (mRNA). They are involved in most biological and pathological processes, including tumorigenesis. The binding of microRNA to mRNA is critical for regulating the mRNA level and protein expression. However, this binding can be affected by single-nucleotide polymorphisms that can ...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2009
ISSN: 1462-2416,1744-8042
DOI: 10.2217/14622416.10.3.399